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Four Things You Need to Know About Molly

From the influence:

Thanks to a string of name-checks by pop stars like Miley Cyrus, Madonna and Kanye West, as well as several tragic deaths at music festivals, ”molly”—aka MDMA—has rarely been far from the headlines in recent years.

 Last winter, a bad batch sent nearly a dozen Wesleyan students to the hospital. Then over the summer, a 19-year-old girl became the second young woman to die after taking the drug at Echostage, a Washington, DC music venue. And in 2013, a University of Virginia student passed away after taking molly—the same weekend two Electric Zoo attendees died after reportedly taking the drug.

 Let’s keep some perspective: Despite its potential to make people sick, it’s also important to remember that the majority of partiers popping molly across the globe don’t end up in the hospital. But why is it that some do?

 “The only people we see either through the emergency room or arrests are people having some kind of significant adverse effect, so we don’t really know what percentage of people who use it end up with these adverse effects,” says Dr. Barry Logan, a toxicologist who has studied molly.

 His insight, along with the published research, dispelled four common misconceptions about the popular party drug.

 1. Molly is not pure MDMA

Dr. Logan swabbed the saliva of 60 attendees who said they took molly at Miami’s Ultra music festival last year, and the results were damning: Only about 17% had ingested actual MDMA.

 Of those 60 people, about 35% had taken ethylone; 25% had taken methylone, and 13% had taken Alpha-PVP. These are all new psychoactive substances similar to MDMA, with A-PVP having more stimulant effects than methylone and ethylone. These newer drugs were, Dr. Logan says, synthesized in response to the prohibition of MDMA. And now they’re routinely passed off as MDMA.

 2. Deaths aren’t always the result of overdose

 Although higher doses of MDMA (and the synthetic cathinones often sold as MDMA) are generally considered riskier, low doses of MDMA can be dangerous too. A 2001 study in the Canadian Medical Association Journal found that while most MDMA-related “serious toxicity or fatality” involves blood levels of MDMA 40 times higher than the typical recreational dose, some fatalities involved doses considered “normal” among recreational users.

“With any drug and with MDMA and some of these substitutes, you absolutely can overdose on them if you take enough,” Dr. Logan says, “but I would say the adverse effects are typically not because people are overdosing. It’s because they’re taking it in a pattern of intensive use—they have some pre-existing risk factor [like a cardiac disease], or they’re taking it in an environment where they’re not hydrating or it’s already hot and they’re increasing their risk.”

 3. The club might not be the best place for molly

 The idea of using molly might evoke a crowd of pulsating partiers illuminated by a club’s light show. But taking molly in a hot, crowded club where water is only accessible behind the bar is a practice with plenty of negatives.

 Dr. Harold Kalant, author of the Canadian study noted earlier, wrote that “perhaps the most dangerous form of toxicity induced by ‘ecstasy’ is a hyperplexic pattern of toxicity that closely resembles heatstroke.”

 Most strikingly, this particularly dangerous reaction to MDMA “has become increasingly frequent since the adoption of MDMA by participants in raves.” MDMA increases body temperature a bit—but dancing in a hot crowd without hydrating greatly exacerbates this effect.

4. The “comedown” is heavily influenced by external factors

 The molly “comedown” is such a dreaded part of the experience that some users find it can sully the high, making them too anxious about how they’ll feel once the molly wears off to relax and enjoy their roll.

 Combining molly with other drugs and alcohol, a predisposition to mental illness, lack of sleep, or the simple fact of going from high to sober have all been linked to negative mood after a roll.
 

Posted: 2/9/2016 3:04:00 PM

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Legal Loophole Closed on Potent Designer Drug

From Courthouse News Service:

The Drug Enforcement Administration issued a final order Friday placing an extremely potent street drug on the schedule of controlled substances after dozens of deaths.

Acetyl fentanyl, which the agency says is 15.7 times more potent than morphine and up to five times more powerful than heroin, is particularly dangerous because the range between the effective dose and the lethal dose is narrow.

The Center of Disease Control issued an alert on acetyl fentanyl in June 2013, after 14 deaths in Rhode Island were attributed to the drug over a three month period.

A total of 39 known deaths have been reported in Rhode Island, North Carolina, California, Louisiana, Oregon and Pennsylvania.

But the Drug Enforcement Administration says it is likely that emergency room admissions and deaths due to this drug are under-reported because "standard immunoassays cannot differentiate acetyl fentanyl from fentanyl."

Other "clandestinely produced fentanyl-like substances, commonly known as designer drugs" have surfaced since the late 1970s and 1980s and been placed on Schedule 1 of the Controlled Substance Act, the Drug Enforcement Administration said.

Due to the "imminent hazard to public safety," today's action by the DEA temporarily places the drug on Schedule 1 under the CSA, and it is effective immediately for up to two years, with a possible extension of one additional year, pending completion of the permanent scheduling process.

Posted: 7/20/2015 11:50:00 AM

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New Webinar- “Flakka”: The Truth Behind the Latest Designer Drug Media Storm

From: NMS Labs

Donna Papsun, a forensic toxicologist at NMS Labs, will be hosting a free webinar on Flakka, the new dangerous designer drug that is taking the country by storm.  "Flakka” is the latest street name referring to alpha-pyrrolidinophenone (alpha PVP), a novel psychoactive substance that has been on the recreational drug market since 2012.  Former street names include “Gravel”, which was allegedly alpha PVP mixed with lorazepam, and “Bath Salts”, a catch-all term referring to a number of synthetic stimulants.  This webinar will focus on the toxicology of alpha PVP and highlight the prevalence of this drug by recreational users.  Although the abuse of alpha PVP is not new, it is certainly a designer drug trend that deserves the attention of public health authorities, law enforcement, medical examiners, and toxicology laboratories. 

Register today and learn more about Flakka, Alpha PVP, and other novel psychoative substances as well as how they are effecting the world of toxicology.  The webinar will be held Monday, June 1st at 1pm and will last roughly a half hour.  You can register for the free webinar here

 

Researchers document drug use among Ultra Music Festival attendees

From: Miami Herald

Fair or not, after 16 years Ultra Music Festival has developed a reputation not only as a cornucopia of lights and sounds, but also as a smorgasbord of psychotropic uppers and downers.  But according to a federally funded study, if you ask 100 audience members to pee in a cup in exchange for a $20 Dunkin’ Donuts gift card, 80 just might test positive for drugs.

At least, researchers from the Center for Forensic Science Research & Education said that was their experience last year when they set up camp outside Bayfront Park and sought to document drug use among the thousands of ticket holders who flock to downtown Miami each year for three days of electronic dance music. The event typically sells more than 160,000 tickets.

Out of 145 voluntary participants, 72 percent admitted to having consumed marijuana, cocaine, molly or ecstasy during the past week. And for the 100-plus brave souls who went a step further and agreed to have their blood taken, or give a urine sample, researchers said they found that 58 percent and 80 percent, respectively, had recently consumed designer drugs.

The goal of the study, according to a summary of the results, was not to find out how many at Ultra are on drugs, but to get a better grasp of “some of the newly emerging and potentially dangerous new drugs popular in the [electronic dance music] community.”

“We found the participants at the event were very open with us about their knowledge of the drug scene and drug use,” said Barry Logan, the Pennsylvania-based center’s executive director. “We found a lot of the time what they thought they were taking was not what they were taking.”

Of the 104 urine samples, more than 80 percent tested positive for a synthetic drug, most commonly molly, followed by Alpha-PVP, a synthetic bath salt known as gravel, which ultimately killed 21-year-old Adonis Peña Escoto last year.

However, Logan said the survey was conducted with far too small a sample size — less than one tenth of a percent of the tickets sold for the festival — to be taken as any kind of statistical representation of the drug use at Ultra.

“A lot of people who read this assume it’s an indicator of prevalence, which I don’t think it is,” said Logan.

Now in its 16th year, Ultra is returning to downtown Miami in late March as an 18-and-older festival.


Read more here: http://www.miamiherald.com/news/local/community/miami-dade/article9709724.html#storylink=cpy

Designer drugs put youths at risk, but recipe changes tie officers’ hands

Via Dallas News

 A week before he died, the 15-year-old honors student had taken an illustrated book to pastures near his Frisco home looking for psychedelic mushrooms. He didn’t find any, so he tried what he thought was LSD on Dec. 14. Convulsions began within an hour after he ingested 25I, a synthetic hallucinogen more potent than LSD. The Collin County medical examiner ruled that his death was connected to the drug. In what appears to be a growing problem, three more overdoses possibly linked to 25I were reported in McKinney last weekend. They appear not to have been fatal.

Efforts to criminalize emerging designer drugs in Texas fell flat in the most recent legislative session, making it more challenging for law enforcement agencies to crack down on the problem.

Nationally, at least 19 deaths have been linked to a set of synthetic drugs known as the NBOMe compounds, including 25I, according to the Drug Enforcement Administration. The users ranged from 15 to 29 years old. Texas Poison Control Network has tallied 25 calls related to NBOMe since 2012. Six came from the Dallas-Fort Worth area.

Stymied in Austin

In November, the DEA temporarily added three NBOMe drugs to Schedule I.  In February, the Department of State Health Services added three NBOMe compounds to the state’s list of controlled substances. The temporary move allows prosecutors to pursue criminal charges, but only misdemeanors, regardless of the amount of the drugs.

Though the state banned K2 in 2011, other kinds of “fake pot” have surfaced since. And if the chemistry is slightly different from what’s in the law, dealers can avoid prosecution.

Law enforcement and public health officials said Huffman’s bills would address that problem by outlawing certain designer drugs and other compounds with the same core chemical structure.

Dueling experts

Like the federal government, Texas has provisions to cover analogs — drugs that are substantially similar to some illegal substances based on their chemical makeup or effects on users.

For every case, prosecutors would have to prove in court that the compound in question was similar enough to an illegal narcotic.

“It comes down to a battle of the expert witnesses,” said Samms, who wrote to lawmakers in support of Huffman’s proposed legislation.

And some cases don’t even make it to court if law enforcement or health officials can’t trace a drug.

NMS Labs in Pennsylvania, which does forensic testing for medical and legal clients across the country, handled its first NBOMe case in 2012.

“They’re very potent, so it takes very little drug to have its effects,” toxicologist Donna Papsun said. “The challenge was creating a test with a low enough detection level so we could properly detect it in the fluids.”

Posted: 4/22/2014 10:42:00 AM

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New synthetic drug investigated in Fishers teen’s death

From: Fox59

HAMILTON COUNTY, Ind. - Police have opened a criminal investigation into the death of a Hamilton County teen who made have died after ingesting synthetic drugs.

John Joseph Romaine, 18, was found unresponsive in his Fishers home Friday evening. According to his obituary, the Hamilton Southeastern High School senior died of cardiac arrest. The Hamilton County coroner is waiting on toxicology results before ruling an official cause, but police are looking into a possible overdose of synthetic drugs.

Police told FOX59 they found illegal drugs inside the home along with three men, including Romaine, who was unconscious.

Officers got there and observed a male lying on the floor and immediately began CPR until medics arrived," said Officer James Alvis, a spokesman for Fisher Police. All three were hospitalized, and Romaine was later pronounced dead.

A Reddit post, which appears to be written by Romaine's older brother, describes the night in detail and points the blame on a new synthetic drug called N-Bomb or NBOME. The author warns people not to use the drug and expressed deep regret over his brother's death.

FOX59 went to St. Vincent Carmel Hospital to find out more about the drug. Emergency room physician Dr. Marcus Hendry explained that it's a psychedelic drug that is often compared to LSD, but it is considered more powerful depending on the purity and dosage.

"They might experience agitation, hallucination, might get high fever, muscle injury, kidney failure, all the way to persistent seizures that may require the induction of a medical coma or even death as a result of persistent seizures or perhaps more commonly death." explained Hendry.

Police are now looking into the Reddit post and warning parents and teens to consider how dangerous synthetic drugs can be. They have not ruled out any arrests in this case.

Posted: 4/10/2014 2:18:00 PM

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School Board Votes to Test Student Athletes for Synthetic Drugs

From: Independant Herald

Synthetic drugs have been added to the substances for which Wyoming County student-athletes may be tested. The Board of Education unanimously approved the addition to the drug testing program at its meeting last Monday night.

“The normal test drugs did not include the synthetic drugs,” said Superintendent of Schools Frank “Bucky” Blackwell.

“Mr. (Jeff) Hylton wanted the board to know that the synthetic drugs are gaining in popularity,” he added. “It’s not actually detected under a regular drug test.

“Anybody who might be using the synthetic drugs would just go scot free,” Blackwell said. “Our whole goal is to catch it in time so that something could be done about it before it gets out of hand or somebody overdoses or has an accident.”

Testing for synthetic drugs is twice as costly as the regular testing, Blackwell noted, “Hopefully the costs will come down.”

“We’ve had great results,” the superintendent remarked. “We don’t catch too many, but we’ve never had a repeat offender.”

If there is a positive test result, Blackwell said, “you have to call Mom and Dad and law enforcement.

“That’s a shocker,” he continued. “Most parents have no idea their child would do something like that. As it has turned out, we have stopped a lot of kids from using drugs.”

Students who test positive are expelled, he pointed out, “and they have straightened up.”

With the addition of synthetic drugs, a student-athlete may be tested for one type of drug or both, Blackwell explained.  “We don’t pick up the phone and ask [the company] to test unless someone is behaving in such a way that would indicate they have a problem.”

He says the board “backs the program 100 percent. It’s paying dividends for our children.

“We feel we have to what we can to help prevent the use of drugs,” Blackwell observed.

Written by John Conely
___________________________________________________________________

This is a great step in the right direction to helping solve the problem of designer drugs, especially with our youth.  Hopefully other districts will join suit and help convey the message that even though some of these drugs may be legal they are still very dangerous and shouldn't be used.
 

Experts Warn of Synthetic Drug Acetyl Fentanyl

From EMS World:

Officials in North Carolina announced they were on the lookout in March for a drug called acetyl fentanyl, which they blame for three deaths in the state.

A CDC health advisory released June 20, 2013 first warned of the drug. “Recently, a number of intravenous drug users have overdosed on a new, non-prescription injected synthetic opioid, acetyl fentanyl,” the release stated.

Between March 2013 and May 2013, 14 overdose deaths related to injected acetyl fentanyl occurred among intravenous drug users in Rhode Island.

When Pennsylvania asked coroners and medical examiners across the state to screen for acetyl fentanyl, the request led to 50 confirmed fatalities and five non-fatal overdoses statewide in 2013, the CDC later reported.

The CDC’s warning recommends increased vigilance by public health agencies, emergency departments, state laboratories, medical examiners and coroners for patients with symptoms consistent with opioid overdose and lab results showing an enzyme-linked immunosorbent assay (ELISA) positive for fentanyl.

Posted: 4/2/2014 11:30:00 AM

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New Synthetic Drug Linked To Teen's Death

From WBIW (Indiana):

Police have opened a criminal investigation into the death of a Hamilton County teen, who made have died after ingesting synthetic drugs.

18-year-old John Joseph Romaine was found unresponsive in his Fishers home Friday evening. According to his obituary, the Hamilton Southeastern High School senior died of cardiac arrest. The Hamilton County coroner is waiting on toxicology results before ruling an official cause, but police are looking into a possible overdose of synthetic drugs.

Police said they found illegal drugs inside the home along with three men, including Romaine who was unconscious.

All three were hospitalized, and Romaine was later pronounced dead.

A Reddit post, which appears to be written by Romaine's older brother, describes the night in detail and points the blame on a new synthetic drug called N-Bomb or NBOME.

E.R. Physician Dr. Marcus Hendry explained that it's a psychedelic drug that is often compared to LSD, but it is considered more powerful depending on the purity and dosage.

Posted: 4/2/2014 10:46:00 AM

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Temporary Placement of 10 Synthetic Cathinones Into Schedule I

From the DEA:

The Deputy Administrator of the Drug Enforcement Administration (DEA) is issuing this final order to temporarily schedule 10 synthetic cathinones into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). This action is based on a finding by the Deputy Administrator that the placement of these synthetic cathinones and their optical, positional, and geometric isomers, salts and salts of isomers into schedule I of the CSA is necessary to avoid an imminent hazard to the public safety. As a result of this order, the regulatory controls and administrative, civil, and criminal sanctions applicable to schedule I controlled substances will be imposed on persons who handle (manufacture, distribute, import, export, engage in research, conduct instructional activities, and possess), or propose to handle these synthetic cathinones.

NOTE:  The 10 substances are: 4-methyl-N-ethylcathinone ("4-MEC"); 4-methyl-alpha-pyrrolidinopropiophenone ("4-MePPP"); alpha-pyrrolidinopentiophenone ("α-PVP"); 1-(1,3-benzodioxol-5-yl)-2-(methylamino)butan-1-one ("butylone"); 2-(methylamino)-1-phenylpentan-1-one ("pentedrone"); 1-(1,3-benzodioxol-5-yl)-2-(methylamino)pentan-1-one ("pentylone"); 4-fluoro-N-methylcathinone ("4-FMC"); 3-fluoro-N-methylcathinone ("3-FMC"); 1-(naphthalen-2-yl)-2-(pyrrolidin-1-yl)pentan-1-one ("naphyrone"); and alpha-pyrrolidinobutiophenone ("α-PBP").


Posted: 3/19/2014 12:15:00 PM

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