Two antidepressants ineffective for dementia

From msnbc.com:

Two antidepressants that are commonly given to Alzheimer's disease patients appear not only to be ineffective but may give side effects such as nausea and drowsiness, a study in Britain has found.

In a paper published in the medical journal The Lancet on Tuesday, researchers urged doctors to think twice before prescribing these drugs to Alzheimer's patients with depression.

The two drugs used in the study were sertraline, marketed by Pfizer under the brand name Zoloft, and mirtazapine, known as Remeron in the United States.

They urged clinicians and investigators to reframe the way they treat Alzheimer's patients with depression and to reconsider routine prescription of antidepressants.

Posted: 7/19/2011 3:05:00 PM

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Combined Sertraline, Naltrexone Treatment May Benefit Depressed, Alcohol-Dependent Patients

From Business Week:

Combined treatment with the antidepressant Zoloft (sertraline) and the alcoholism drug naltrexone improves the likelihood that people with both major depression and alcohol dependence will be able to stop drinking, U.S. researchers report.

Their 14-week study of 170 patients found that 54 percent of those who received the combined treatment were able to stop drinking, compared with 21 to 28 percent for patients who received a placebo, Zoloft only, or naltrexone only.

The patients who received the combined treatment also went for a longer period of time before they started drinking again -- 61 days compared with 15 days for patients in the other groups.

The findings may prove an important advance in the treatment of patients with alcohol dependence and depression, said the University of Pennsylvania researchers.

The study was published March 15 in the The American Journal of Psychiatry.

Posted: 3/16/2010 1:24:00 PM

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