From
WebMD:
Taking the epilepsy drug
topiramate (Topamax) during pregnancy raises the risk of oral cleft birth defects such as cleft lip and cleft palate, according to a new warning issued by the FDA.
New drug registry data show that the risk of oral birth defects is up to 16 times higher among women who took topiramate or its generic equivalents during pregnancy.
Topiramate is approved by the FDA for treating seizures associated with epilepsy and to prevent migraines. But it is also sometimes used on an off-label basis to treat other conditions, such as obesity, bipolar disorder, and alcoholism.